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Product Name
Human LILRB4/CD85k/ILT3 (Fc Tag) recombinant protein
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Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {PubMed:11875462, PubMed:9151699}.
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Protein name
Leukocyte immunoglobulin-like receptor subfamily B member 4
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Protein short names
ILT3; LIR5
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Uniprot ID
Q8NHJ6
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Gene Name
LILRB4; ILT3; LIR5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human LILRB4 (NP_001265356.2) (Met1-His257) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human LILRB4 consists of 475 amino acids and predicts a molecular mass of 52.8 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human LILRB4/CD85k/ILT3 Protein (Fc Tag)
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