Human KNG1/BDK/KNG (His tag) recombinant protein

Human KNG1/BDK/KNG (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.

kininogen 1(KNG1)

BDK; KNG

P01042

Human Cells

A DNA sequence encoding the Human KNG1/BDK/KNG Gln19-Ser427 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.