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Product Name
Human KLK6/Kallikrein 6/Neurosin (His Tag) recombinant protein
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Description
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
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Protein short names
SERINE PROTEASE 18; MYELENCEPHALON-SPECIFIC PROTEASE; KALLIKREIN 6; ZYME; NEUROSIN; PROTEASE M; MYOFIBRIL-BOUND PROTEASE; PRSS18; KALLIKREIN-6; SP59; BRAIN SERINE PROTEASE; PRSS9; SERINE; HK6; BSSP; BSP; KLK7; AI849898; SERINE PROTEASE 9; PROTEASE; KLK29; MSP; KALLIKREIN 29
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Uniprot ID
Q92876
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KLK6 isoform 1 (Q92876-1) (Met 1-Lys 244), was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human KLK6 (pro form) consists of 239 amino acids and has a predicted molecular mass of 26.6 kDa. The apparent molecular mass of rhKLK6 is approximately 10&25 kDa in SDS-PAGE under reducing conditions due to autolysis.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC, R&D Systems, Catalog # ES014.
The specific activity is > 250 pmols/min/μg. -
Validations
Human KLK6 / Kallikrein 6 / Neurosin Protein (His Tag) SDS-PAGE
Related Products / Services
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