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Product Name
Human KIR2DL4 / CD158D (Fc Tag) recombinant protein
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Description
KIR2DL4, also known as CD158d, is a member of the killer cell Ig-like receptor (KIR) family. KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
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Protein short names
KIR103; NATURAL KILLER CELL INHIBITORY RECEPTOR; MHC CLASS I NK CELL RECEPTOR KIR103AS; NK CELL RECEPTOR; KIR-103AS; XXBAC-BCX195L8.3; KILLER IG RECEPTOR; CD158D; KILLER CELL INHIBITORY RECEPTOR 103AS; KIR103AS; 4; KIR2DL4; G9P; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR; LONG CYTOPLASMIC TAIL; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL4; TWO DOMAINS; CD158 ANTIGEN-LIKE FAMILY MEMBER D
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human KIR2DL4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 462 amino acids and has a predicted molecular mass of 51.3 kDa. The apparent molecular mass of the protein is approximately 62, 34 and 32 kDa in SDS-PAGE under reducing conditions.
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Purity
(75.1+13.2+10.1) % as determined by SDS-PAGE
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Validations
Human KIR2DL4 / CD158D Protein (Fc Tag) SDS-PAGE
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