Human KIAA0776 Recombinant protein (His tag)

Human KIAA0776 Recombinant protein (His tag)

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E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). {PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:23152784, PubMed:25219498}.

E3 UFM1-protein ligase 1

KIAA0776; NLBP; RCAD

O94874

UFL1; KIAA0776; NLBP; RCAD

E. coli

A DNA sequence encoding the human UFL1 (NP_056138.1) 1-350 aa was fused with the polyhistidine tag

Human

Not tested.