Human IL23R / IL23 Receptor (Fc Tag) recombinant protein

Human IL23R / IL23 Receptor (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.

IL-23R; IL-23 RECEPTOR; INTERLEUKIN-23 RECEPTOR

Human Cells

A DNA sequence encoding the human IL23R (Met1-Asp353) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human IL23R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a predicted molecular mass of 64.9 kDa. The apparent molecular mass of the protein is approximately 92, 58 and 37 kDa in SDS-PAGE under reducing conditions.

(45+17.3+30.1) % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
1. Immobilized human IL23A-His+IL12B-His (Cat:CT012-H08H) at 10 μg/ml (100 μl/well) can bind human IL23R-Fc. The EC₅₀ of human IL23R-Fc is 0.28-0.66 μg/ml.
2. Immobilized mouse IL12Bh (m)+mIL23Ah (Cat:CT028-M08H) at 10 μg/ml (100 μl/well) can bind human IL23R-Fc. The EC₅₀ of human IL23R-Fc is 0.14-0.35 μg/ml.