Human IFNA7 recombinant protein (C-His)

Human IFNA7 recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

Interferon alpha-7(IFNA7) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Human IFN are divided on the sequence of amino-acids into three groups: Alpha, Beta and Gamma interferons.

Interferon alpha-7

IFN-alphaJ,IFNA-J

P01567

Interferon alpha-7; IFN-alpha-7; Interferon alpha-J; LeIF J; Interferon alpha-J1; IFN-alpha-J1

Yeast

A DNA sequence encoding the human IFNA7 (NP_066401.2) (Cys24-Asp189) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human IFNA7 consists of 176 amino acids and predicts a molecular mass of 21 kDa.

> 95 % as determined by SDS-PAGE.

Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED₅₀ for this effect is 3.0-15.0pg/mL.