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  • human Histatin 1 peptide

human Histatin 1 peptide

Not For Human Use, Lab Use Only.

Cat.#: 301359

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    human Histatin 1 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN, S2=phosphorylated serine
  • Sequence
    Asp-pSer-His-Glu-Lys-Arg-His-His-Gly-Tyr-Arg-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Glu-Phe-Pro-Phe-Tyr-Gly-Asp-Tyr-Gly-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn
  • Length (aa)
    38
  • Peptide Purity (HPLC)
    98.3%
  • Molecular Formula
    C217H298N69O64P
  • Molecular Weight
    4928.16
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Histatin-1 is a histidine-rich peptide found in human saliva, belonging to a family of peptides exclusive to higher primates. It is encoded by the HTN1 gene and is secreted by the parotid and submandibular glands. The peptide is characterized by seven histidine residues and a phosphorylated serine at residue 2.

    Scientific studies demonstrate that Histatin-1 specifically promotes cellular adhesion. It significantly enhances cell-substrate adhesion, increasing the ability of adherent cells to attach and spread on surfaces, with an effective concentration (EC50) of 1 µM. This effect is not observed with other histatins, indicating specificity. Furthermore, Histatin-1 strengthens cell-cell adhesion, as evidenced by increased transepithelial electrical resistance in epithelial cell layers, suggesting a role in enhancing epithelial integrity. The peptide is internalized by cells and its activity is linked to its specific amino acid sequence and phosphorylation state.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • van Dijk IA, Nazmi K, Bolscher JG, Veerman EC, Stap J. Histatin-1, a histidine-rich peptide in human saliva, promotes cell-substrate and cell-cell adhesion. FASEB J. 2015 Aug;29(8):3124-32. doi: 10.1096/fj.14-266825. Epub 2015 Apr 22. PMID: 25903106.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"