Human HHLA2 recombinant protein (C-human IgG1-Fc)

Human HHLA2 recombinant protein (C-human IgG1-Fc)

• DataSheet
• Material Safety Data Sheets (MSDS)

B7H7 gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.
HERV–H LTR-associating 2 (HHLA2, also called B7H7/B7-H5/B7y)has been recently discovered as the newest member of the B7 family and has 23–33% similarity in amino acid sequence with the other B7 molecules. This ligand is the only B7 family member that is found in humans but not in mice. It is constitutively expressed on the surface of human monocytes and is induced on B cells. HHLA2 binds to its putative receptor(s) on a variety of immune cells including CD4 and CD8 T cells and antigen-presenting cells. Similarly to B7-H3, both a T cell coinhibitory role as well as a costimulatory role has been reported for this ligand.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

HERV-H LTR-associating protein 2

B7-H7,B7H7,HHLA2

Q9UM44

HERV-H LTR-associating protein 2; Human endogenous retrovirus-H long terminal repeat-associating protein 2

Human Cells

A DNA sequence encoding the human HHLA2 (NP_009003.1) (Met1-Asn344) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human HHLA2 consists 560 amino acids and predicts a molecular mass of 63.7 kDa.

> 90 % as determined by SDS-PAGE.

5820.00