Human Frizzled-10/FZD10 (CD350) (Fc Tag) recombinant protein

Human Frizzled-10/FZD10 (CD350) (Fc Tag) recombinant protein

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Mouse Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Frizzled homolog 10 (Drosophila)

Q9ULW2

FZD10

Human Cells

A DNA sequence encoding the human FZD10 (NP_009128.1) (Met1-Gly161) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human FZD10/Fc comprises 379 amino acids and has a predicted molecular mass of 42.8 kDa. The apparent molecular mass of the protein is approximately 48.7 kDa in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE