Human FOP / FGFR1OP (His & GST Tag) recombinant protein

Human FOP / FGFR1OP (His & GST Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.

FGFR1 ONCOGENE PARTNER; FOP; 4930553O10RIK; FGFR1OP; FIBROBLAST GROWTH FACTOR RECEPTOR 1 ONCOGENE PARTNER

Baculovirus-Insect Cells

A DNA sequence encoding the human FGFR1OP ( Ala2-Ala379) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Human

The secreted recombinant human FGFR1OP consists of 615 amino acids and predicts a molecular mass of 68.6 KDa. The apparent molecular mass of the protein is approximately 69 KDa in SDS-PAGE under reducing conditions due to glycosylation.

> 85 % as determined by SDS-PAGE