Human FGF6 / FGF-6 recombinant protein

Human FGF6 / FGF-6 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene displayed oncogenic transforming activity when transfected into mammalian cells.

HST2; HBGF-6; HEPARIN SECRETORY-TRANSFORMING PROTEIN 2; FGF6; HST-2; FIBROBLAST GROWTH FACTOR 6; HSTF-2; FGF-6; HEPARIN-BINDING GROWTH FACTOR 6

E. coli

A DNA sequence encoding the mature form of human FGF6 (Gly41-Ile208) was expressed with a N-terminal Met.

Human

The recombinant human FGF6 consists of 169 amino acids and predicts a molecular mass of 18.9 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts.
The ED₅₀ for this effect is typically 0.1-0.6 ng/mL.