Human FGF23/HYPF/UNQ3027/PRO9828 (His tag) recombinant protein

Human FGF23/HYPF/UNQ3027/PRO9828 (His tag) recombinant protein

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Fibroblast Growth Factor 23 (FGF-23) is a secreted protein that belongs to the heparin-binding growth factors family. FGF-23 is expressed in osteogenic cells, particularly during phases of active bone remodeling. FGF family members possess broad mitogenic and cell survival activities, involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-23 regulates homeostasis of phosphate and vitamin-D metabolism. FGF-23 inhibits renal tubular phosphate transport by reducing SLC34A1 levels, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 also upregulates EGR1 expression in the presence of KL, acts directly on the parathyroid to decrease PTH secretion. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR).

fibroblast growth factor 23(FGF23)

HYPF; UNQ3027; PRO9828

Q9GZV9

Human Cells

A DNA sequence encoding the Human FGF23/HYPF/UNQ3027/PRO9828 Tyr25-Ile251 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.