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  • Human FGF21/UNQ3115/PRO10196 (His tag) recombinant protein

Human FGF21/UNQ3115/PRO10196 (His tag) recombinant protein

Cat.#: 519741

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Product Information

  • Product Name
    Human FGF21/UNQ3115/PRO10196 (His tag) recombinant protein
  • Documents
  • Description
    Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet.Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.
  • Protein name
    fibroblast growth factor 21(FGF21)
  • Protein short names
    UNQ3115; PRO10196
  • Uniprot ID
    Q9NSA1
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human FGF21/UNQ3115/PRO10196 His29-Ser209 is expressed with a 6His tag at the N-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human FGF21/UNQ3115/PRO10196 (His tag) recombinant protein

    Human FGF21/UNQ3115/PRO10196 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"