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Product Name
Human FCGRT & B2M recombinant protein
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Description
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.
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Protein name
IgG receptor FcRn large subunit p51
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Protein short names
FCRN
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Uniprot ID
P55899
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Gene Name
FCGRT; FCRN
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Ser 297) of human FCGRT (P55899) was fused with a polyhistidine tag at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the human B2M (P61769) (Met 1-Met 119) constructed the plasmid 2. The two plasmids were co-expressed and the FCGRT / B2M heterodimer was purified.
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Protein Species
Human
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Molecular weight
The recombinant heterodimer of human FCGRT/B2M comprises 385 (285 + 100) amino acids and has a calculated molecular mass of 43.5 (31.8 + 11.7) kDa. The apparent molecular mass of rh FCGRT/B2M heterodimer is approximately 35 & 12 kDa respectively in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind human IgG1 in a functional ELISA.
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Validations
Human FCGRT & B2M Heterodimer Protein SDS-PAGE
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