Human EGFL6 / EGF-L6 (Flag & His Tag) recombinant protein
EGFL6, also known as EGF-L6, belongs to the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. EGFL6 contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. EGFL6 gene is expressed early during development, and its expression has been detected in lung and meningioma tumors.
Epidermal growth factor-like protein 6
Protein short names
EGFL6; EGF-LIKE PROTEIN 6; MULTIPLE 6; EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 6; MAEG; EGF REPEAT-CONTAINING PROTEIN 6; PP648; MAM AND EGF DOMAINS-CONTAINING GENE PROTEIN; MULTIPLE 6; MAM AND EGF DOMAIN CONTAINING; W80; EGF-LIKE-DOMAIN; RP23-408K4.7
EGFL6; MAEG; PP648; UNQ281/PRO320
A DNA sequence encoding the human EGFL6 (NP_056322.2) (Asn22-Asp553) was expressed with the flag tag at the N-terminus and the histidine tag at the C-terminus.
The recombinant human EGFL6 consists of 551 amino acids and has a calculated molecular mass of 61.5 kDa.
> 65 % as determined by SDS-PAGE
Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells.When 5 × 10E4 cells/well areadded to CD4 coated plates (1.25μg/mL and 100μL/well),approximately 40%-60% will adhere specifically after 30 minutes at 37℃.
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