Human DPY30 domain containing 2 (GST Tag) recombinant protein

Human DPY30 domain containing 2 (GST Tag) recombinant protein

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DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family involved in chromatin modifications, notably histone methylation. Mutants affect mating type in yeast and male mating in C. elegans. As part of the MLL1/MLL complex, DPY30 domain containing 2 is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. DPY30 domain containing 2 may also play an indirect or direct role in endosomal transport.

MGC16186; DPY30 DOMAIN-CONTAINING PROTEIN 2; MGC130531; BA36D19.6; 4933428D01RIK

E. coli

A DNA sequence encoding the mature form of human DYDC2\ (Q96IM9) (Thr102-Pro176) was fused with the GST tag at the N-terminus.

Human

The recombinant human DYDC2 /GST chimera consists of 307 amino acids and has a predicted molecular mass of 35.5 kDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions.

> 93 % as determined by SDS-PAGE