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Product Name
Human DFFA/DFF1/DFF45/H13 (His tag) recombinant protein
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Description
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
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Protein name
DNA fragmentation factor subunit alpha(DFFA)
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Protein short names
DFF1; DFF45; H13
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Uniprot ID
O00273
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human DFFA/DFF1/DFF45/H13 Met1-Thr331 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human DFFA/DFF1/DFF45/H13 (His tag) recombinant protein
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