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  • Human Defensin-5 (1-9) peptide

Human Defensin-5 (1-9) peptide

For research use only. We do not sell to patients.

Cat.#: 318760

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 78.0 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Human Defensin-5 (1-9) peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-ATCYCRTGR-Amidation
  • Three letter code
    H-Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Amidation
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C40H68N16O12S2
  • Molecular Weight
    1029.19
  • Source
    Synthetic
  • Additional Information
    Human alpha-defensin(HD-5) is a strong activity antimicrobial peptide. HD-5(1–9) treatment affects certain bacterial genera and transiently increases microbial diversity in the small intestine. Mice treated orally with HD-5(1–9) had an increased amount of Akkermansia sp. compared with nontreated mice. Moreover, in contrast to other bacteria, Akkermansia muciniphila was not susceptible to HD-5(1–9) in a turbidity broth assay. MS showed that Human Defensin-5 (1-9) had a M.W.=1029.45 dalton
  • Storage Guidelines
    Ideally Human Defensin-5 (1-9) peptide should be stored in a freezer at or below -9C. Human Defensin-5 (1-9) peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Ehmann D, Wendler J, Koeninger L, et al. Paneth cell u03b1-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. Proc Natl Acad Sci U S A. 2019;116(9):3746-3751
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-ATCYCRTGR-Amidation
  • Chemical Formula:C40H68N16O12S2
  • Sequence length:9
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:-0.59
  • Mw average:1029.19
  • Theoretical pI:9.08
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"