Human CXCL13 recombinant protein (Native)

Human CXCL13 recombinant protein (Native)

• DataSheet
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The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).

C-X-C motif chemokine 13

ANGIE,ANGIE2,BCA-1,BCA1,BLC,BLR1L,SCYB13

O43927

C-X-C motif chemokine 13; Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13

E. coli

A DNA sequence encoding the human CXCL13 (NP_006410.1) (Val23-Arg94) was expressed with an initial Met.

Human

The recombinant human CXCL13 consists of 73 amino acids and predicts a molecular mass of 8.8 kDa.

> 95 % as determined by SDS-PAGE.