Human CNGA3 Recombinant protein (GST tag)

Human CNGA3 Recombinant protein (GST tag)

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Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {, PubMed:10888875}.

Cyclic nucleotide-gated cation channel alpha-3

CNCG3

Q16281

CNGA3; CNCG3

E. coli

A DNA sequence encoding the human CNGA3 (XP_011508856.1) 645-749 aa was fused with the N-terminal GST tag

Human

Not tested.