Human CHOP; GADD153 Recombinant protein (His tag)

Human CHOP; GADD153 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. {PubMed:15322075, PubMed:15775988, PubMed:16434966, PubMed:17709599, PubMed:18940792, PubMed:19672300, PubMed:20829347, PubMed:20876114, PubMed:22761832}.

DNA damage-inducible transcript 3 protein

CHOP; CHOP10; GADD153

P35638

DDIT3; CHOP; CHOP10; GADD153

E. coli

A DNA sequence encoding the human DDIT3 (NP_001181983.1) 24-192 aa was fused with the polyhistidine tag

Human

Not tested.