Human CD8B / P37 / LEU2 recombinant protein

Human CD8B / P37 / LEU2 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.

CD8B; T-CELL MEMBRANE GLYCOPROTEIN LY-3; LEU2; BETA POLYPEPTIDE 1 (P37); T LYMPHOCYTE SURFACE GLYCOPROTEIN BETA CHAIN; LY3; LYT-3; T-CELL SURFACE GLYCOPROTEIN LYT-3; T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN; LY-3; P37; LY-C; CD8 ANTIGEN; LYMPHOCYTE ANTIGEN 3; LYT3; CD8B1

Human Cells

A DNA sequence encoding the extracellular domain of human CD8B (P10966-1) (Met1-Pro170) was expressed with six amino acids (LEVLFQ) at the C- terminus.

Human

The recombinant human CD8B comprises 156 amino acids and has a predicted molecular mass of 17.6 kDa. The apparent molecular mass of the protein is approximately 27.3 kDa in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE