Cart 2
  • Human CD33 recombinant protein (C-cleavage)
  • Human CD33 recombinant protein (C-cleavage)

Human CD33 recombinant protein (C-cleavage)

Cat.#: 514922

Size:

Special Price 800.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human CD33 recombinant protein (C-cleavage)
  • Documents
  • Description
    Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein short names
    p67,Siglec-3,SIGLEC3
  • Uniprot ID
    AAH28152.1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CD33 (AAH28152.1) (Met1-His259) was expressed with five amino acids (DDDDK) at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CD33 consists of 248 amino acids and predicts a molecular mass of 27.4 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human CD33/Siglec-3 Protein 15520

    Human CD33/Siglec-3 Protein 15520

    Human CD33 / Siglec-3 Protein

    Human CD33 / Siglec-3 Protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"