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Human CD300A (Fc Tag) recombinant protein

Cat.#: 503204

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Product Information

  • Product Name
    Human CD300A (Fc Tag) recombinant protein
  • Documents
  • Description
    Mouse CMRF35-like molecule 8, also known as CD300 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a and CMRF35H, is a single-pass type I membrane protein which belongs to the CD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b, CD300e ) and inhibitory members ( CD300a, CD300f ), as well as molecules presenting a negative charge within their transmembrane domain ( CD300c, CD300d ).  CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.It contains one Ig-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor Fc?R?. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
  • Protein name
    CMRF35-like molecule 8
  • Protein short names
    LMIR1; MCPIR1; CMRF35H; IRC1/IRC2; CLM8; IRC1; IGSF12; CMRF35-H9; CMRF-35-H9; CLM-8; B230315M08RIK; IRP60; MMAC8; PIGR4; MAIR-I; CMRF35-H; IRC2; CD300A; MAIR-IA; CMRF-35H; RP23-254J18.3; CMRF35H9
  • Uniprot ID
    Q9UGN4
  • Gene Name
    CD300A; CMRF35H; IGSF12; HSPC083
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CD300A (Q9UGN4-1)(Met1-Gln178) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CD300A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and has a predicted molecular mass of 44.5 kDa. The apparent molecular mass of the protein is approximately 58-66 kDa in SDS-PAGE under reducing conditions.
  • Purity
    (97.9+1.1) % as determined by SDS-PAGE
  • Validations

    Human CD300A Protein (Fc Tag) SDS-PAGE

    Human CD300A Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"