Human CD28 recombinant protein

Human CD28 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

CD28; TP44; CH29-189K17.3; MGC138290

Human Cells

A DNA sequence encoding the human CD28 (P10747-1) (Met 1-Pro 152) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Human

The recombinant human CD28 consists of 141 amino acids and predicts a molecular mass of 15.9 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE