Human CD24/CD24A (Fc tag) recombinant protein

Human CD24/CD24A (Fc tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

CD24 molecule(CD24)

CD24A

P25063

Human Cells

A DNA sequence encoding the Human CD24/CD24A Ser27-Gly59 is expressed with a Fc tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.