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Human CADM4/IGSF4C/NECL-4 (Fc Tag) recombinant protein

Cat.#: 503591

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Product Information

  • Product Name
    Human CADM4/IGSF4C/NECL-4 (Fc Tag) recombinant protein
  • Documents
  • Description
    Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.
  • Protein name
    Cell adhesion molecule 4
  • Protein short names
    NECL-4; NECL4; CADM4; IGSF4C; TSLL2; SYNCAM4; IGDF4C
  • Uniprot ID
    Q8NFZ8
  • Gene Name
    CADM4; IGSF4C; NECL4; TSLL2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CADM4 (NP_660339.1) (Met1-Tyr323) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CADM4 consists 541 amino acids and predicts a molecular mass of 60.1 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human CADM4 / IGSF4C / NECL-4 Protein (Fc Tag)

    Human CADM4 / IGSF4C / NECL-4 Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"