-
Product Name
Human BTN2A1/BT2.1/BTF1 (His tag) recombinant protein
- Documents
-
Description
Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletions in the cytoplasmic region. BTN2A1 is widely expressed including on colonic epithelial cells, on immune cells, and in milk fat globules. It binds to the C-type lectin DCSIGN on monocytederived dendritic cells, and this interaction can be blocked by soluble gp130 from HIV. The polymorphism of BTN2A1 has been associated with metabolic syndrome, type II diabetes mellitus, chronic kidney disease, and hypertension.
-
Protein name
butyrophilin subfamily 2 member A1(BTN2A1)
-
Protein short names
BT2.1; BTF1
-
Uniprot ID
Q7KYR7
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the Human BTN2A1/BT2.1/BTF1 Gln29-Ala248 is expressed with a 6His tag at the C-terminus.
-
Protein Species
Human
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Human BTN2A1/BT2.1/BTF1 (His tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"