Human BAZ1B Recombinant protein (His tag)

Human BAZ1B Recombinant protein (His tag)

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• Material Safety Data Sheets (MSDS)

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {PubMed:11980720, PubMed:15543136, PubMed:16603771, PubMed:19092802, PubMed:19234442}.

Tyrosine-protein kinase BAZ1B

WBSC10; WBSCR10; WBSCR9; WSTF

Q9UIG0

BAZ1B; WBSC10; WBSCR10; WBSCR9; WSTF

E. coli

A DNA sequence encoding the human BAZ1B (NP_001357331.1) 1144-1483 aa was fused with the polyhistidine tag

Human

Not tested.