-
Product Name
Human B7-H5 / GI24 / VISTA (Fc Tag) recombinant protein
- Documents
-
Description
C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
-
Protein name
Platelet receptor Gi24
-
Protein short names
RP11-472K8.3; GI24; PLATELET RECEPTOR GI24; STRESS INDUCED SECRETED PROTEIN 1; B7-H5; B7H5; SISP1; PP2135
-
Uniprot ID
Q9H7M9
-
Gene Name
C10orf54; SISP1; PP2135; UNQ730/PRO1412
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human C10orf54 (AAH20568.1) (Met1-Ala194) was expressed with the Fc region of human IgG1 at the C-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human C10orf54 consists 400 amino acids and predicts a molecular mass of 44.9 kDa.
-
Purity
> 95 % as determined by SDS-PAGE.
-
Validations
C10orf54 protein SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"