Human B3GNT6 (aa 44-384, His Tag) recombinant protein

Human B3GNT6 (aa 44-384, His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

B3GNT6 belongs to the glycosyltransferase 31 family. B3GNT6 play s an important role in the synthesis of mucin-type O-glycans in digestive organs. It catalyzes the transfer of GlcNAc from UDP-GlcNAc to GalNAcalpha1-Ser/Thr (Tn antigen) to form the core 3 structure (GlcNAcbeta1-3GalNAcalpha1-Ser/Thr). Core 3 structure exists in O-glycan which is an important precursor in the biosynthesis of mucin-type glycoproteins. Loss of core 3 could lead to the production of secreted mucins, then bacteria would be inefficiently cleared from the system, and chronic inflammation would be developed, which eventually would result in development of cancer. B3GNT6 gene is a tumor suppressor gene.

UDP-GLCNAC:BETAGAL BETA-1; CORE 3 SYNTHASE; 3-N-ACETYLGLUCOSAMINYLTRANSFERASE PROTEIN; BETA3GN-T6; 3-GN-T6; B3GN-T6; B3GNT6; 3-N-ACETYLGLUCOSAMINYLTRANSFERASE 6; CORE-3; BETA 1; BGNT-6; BC039789; UDP-GLCNAC:BETAGAL; BETA-1; IMAGE:4907098; CORE3

Baculovirus-Insect Cells

A DNA sequence encoding the human B3GNT6 (Gln44-Ser384) was fused with a polyhistide tag at the N-terminus.

Human

The recombinant human B3GNT6 consists of 357 amino acids and has a calculated molecular mass of 40 kDa. The recombinant protein migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE