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Product Name
Human ASXL1/KIAA0978 (GST tag) recombinant protein
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Description
Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.
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Protein name
additional sex combs like 1, transcriptional regulator(ASXL1)
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Protein short names
KIAA0978
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Uniprot ID
Q8IXJ9
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human ASXL1/KIAA0978 Lys1477-Arg1541 is expressed with a GST tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human ASXL1/KIAA0978 (GST tag) recombinant protein
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