Human ANAPC11 Recombinant protein (His tag)

Human ANAPC11 Recombinant protein (His tag)

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Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {PubMed:11739784, PubMed:18485873}.

Anaphase-promoting complex subunit 11

Q9NYG5

ANAPC11; HSPC214

E. coli

A DNA sequence encoding the human ANAPC11 (NP_001002244.1) 1-196 aa was fused with the polyhistidine tag

Human

Not tested.