Human ABCB5 (Trx tag) recombinant protein

Cat.#: 518926

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Product Information

  • Product Name
    Human ABCB5 (Trx tag) recombinant protein
  • Documents
  • Description
    ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
  • Protein name
    ATP binding cassette subfamily B member 5(ABCB5)
  • Uniprot ID
    Q2M3G0
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human ABCB5 Ile141-Val247 is expressed with a Trx tag at the N-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human ABCB5 (Trx tag) recombinant protein

    Human ABCB5 (Trx tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"