Human ABCB5 (Trx tag) recombinant protein

Human ABCB5 (Trx tag) recombinant protein

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ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.

ATP binding cassette subfamily B member 5(ABCB5)

Q2M3G0

E. coli

A DNA sequence encoding the Human ABCB5 Ile141-Val247 is expressed with a Trx tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.