Hp1404 peptide

Hp1404 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GILGKLWEGVKSIF

Gly-Ile-Leu-Gly-Lys-Leu-Trp-Glu-Gly-Val-Lys-Ser-Ile-Phe

14

96.8%

Synthetic

Powder

~82% similar to AP2334: scorpion Hp1036. Active against only tested Gram-positive bacteria, including S. aureus AB94004 (also others strains ATCC25923, ATCC6538, AB208193), S. epidermidis AB208187 (also AB208188), M. luteus AB93113, B. subtilis AB91021, S. aureus MRSA P1381, S. aureus MRSA P1374, E. faecium, and S. agalactiae (MIC 4-16 uM). Animal model:mouse peritonitis model, the injected peptide did protect the mice in vivo compared to the untreated group. Serum, but not salt, might have reduced peptide activity in vivo (Salt-insensitive but serum-sensitive). Hp1404 was found in Heterometrus petersii.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Li Z, Xu X, Meng L, et al. Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. PLoS ONE. 2014;9(5):e97539.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.