HOXB7 8-25 peptide

HOXB7 8-25 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-PLLLKLLKSVGAQKD-OH

H-Pro-Leu-Leu-Leu-Lys-Leu-Leu-Lys-Ser-Val-Gly-Ala-Gln-Lys-Asp-OH

15

95.91%

C₇₅H₁₃₅N₁₉O₂₀

1622.98

Synthetic

Powder

HOXB7 8–25 is a novel Homeobox B7 (HOXB7) derived peptide epitope, identified as having the potential to bind to multiple HLA-DRs (DR1, 4, 7, 11, and 15) and target HOXB7 expressing tumours through immune cells. HOXB7 is a master regulatory gene that regulates cell proliferation and activates oncogenic pathways, and overexpression of HOXB7 correlates with poor prognosis in cancer. In human head and neck squamous cell carcinoma (HNSCC) tissue HOXB7 8-25 shows direct cytotoxicity and antigen specific and tumour reactive promiscuous CD4+ T cell responses, producing γ-interferon and directly killing tumours through granzyme B. HOXB7 is thus demonstrated to be a potential target for cancer immunotherapy,

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Komatsuda et al (2022) Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation. Cancer Sci. 2022 Epub ahead of print. PMID: 36285482

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.