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  • Hoe 140 peptide

Hoe 140 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319003

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* Buy 1 get 1 free (?) What is TFA?

Special Price 376.30 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Hoe 140 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    RRPXGXSXXR, Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic
  • Sequence
    H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    95.28%
  • Molecular Formula
    C59H89N19O13S
  • Molecular Weight
    1304.5
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Hoe 140, also known as icatibant, is a potent and selective bradykinin B2 receptor antagonist with a pA2 of 9.04. Hoe 140 also inhibits aminopeptidase N with a Ki of 9.1 μM. Hoe 140 is antinociceptive and anti-inflammatory in a number of acute nociceptive animal models.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851
    • Perkins et al (1993) Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain 53(2) 191 PMID: 8393171
    • Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"