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  • HKPao or Adipotide peptide

HKPao or Adipotide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319610

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Product Information

  • Product Name
    HKPao or Adipotide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    cKGGRAKDCGGklaklakklaklak
  • Sequence
    {d-Cys}-KGGRAKDCGG-{d-(Lys-Leu-Ala-Lys-Leu-Ala-Lys)}2
  • Length (aa)
    25
  • Peptide Purity (HPLC)
    95.23%
  • Molecular Formula
    C111H206N36O28S2
  • Molecular Weight
    2557.18
  • CAS No.
    859216-15-2
  • Source
    Synthetic
  • Form
    Powder
  • Description

    HKPao, also known as Adipotide, is a synthetic hunter-killer peptide composed of two distinct domains. The amino-terminal homing sequence specifically interacts with cell surface receptors, facilitating targeted intracellular delivery. This domain is connected via a glycinyl glycine linker to a conserved carboxyl-terminal pro-apoptotic sequence, which consists of D-amino acids to enhance stability.

    The peptide enters cells through receptor-mediated interactions and migrates toward mitochondria. Experimental studies demonstrate that HKPao induces the formation of transient pores in phospholipid vesicle membranes without causing lysis. These pores are sufficiently large to permit the efflux of entrapped cytochrome c, indicating a membrane-perturbing mechanism. The peptide exhibits a graded mode of leakage, where vesicles retain partial contents post-treatment, and the pore size allows selective release of molecules based on hydrodynamic radius.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Sandoval CM, Salzameda B, Reyes K, Williams T, Hohman VS, Plesniak LA. Anti-obesity and anti-tumor pro-apoptotic peptides are sufficient to cause release of cytochrome c from vesicles. FEBS Lett. 2007;581(28):5464-5468. doi:10.1016/j.febslet.2007.10.051
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"