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Product Name
HIV gp140 (Fc Tag) recombinant protein
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Protein short names
SIMA135; AA409659; 9030022E12RIK; E030027H19RIK; TRASK; CD318; GP140
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the HIV-1 envelope glycoprotein gp160 extracellular domain (Ala 29-Ser 661), termed as gp140, was fused with the Fc region of human IgG1 at the C-terminus and a signal peptide at the N-terminus.
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Protein Species
HIV
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Molecular weight
The recombinant HIV-1 gp140 consists of 874 amino acids after removal of the signal peptide and has a predicted molecular mass of 98 kDa. The apparent molecular mass of the recombinant protein is approximately 210-230 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Using the Octet RED System, the affinity constant (Kd) of gp140-Fc bound to human CD4 is 0.3 μM.
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Validations
Human Immunodeficiency Virus type 1 (HIV-1) gp140 Protein (Fc Tag) SDS-PAGE
Related Products / Services
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