HIV HIV gp120 (His Tag) recombinant protein

Cat.#: 504568

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Product Information

  • Product Name
    HIV HIV gp120 (His Tag) recombinant protein
  • Documents
  • Description
    The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.
  • Protein short names
    GP120; HIV-1 GP120; HIV GP120; HIV1 GP120; SURFACE GLYCOPROTEIN GP120; SURFACE GLYCOPROTEIN 120
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the HIV-1 Envelope glycoprotein gp160 protein (Trp32-Arg504) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    HIV
  • Molecular weight
    The recombinant HIV-1 Envelope glycoprotein gp160 protein consists 484 amino acids and predicts a molecular mass of 54.4 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    GP120 protein SDS-PAGE

    GP120 protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"