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  • HIV gag peptide (197-205)

HIV gag peptide (197-205)

Not For Human Use, Lab Use Only.

Cat.#: 319806

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    HIV gag peptide (197-205)
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-AMQMLKETI-OH
  • Sequence
    H-Ala-Met-Gln-Met-Leu-Lys-Glu-Thr-Ile-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.9%
  • Molecular Formula
    C45H81N11O14S2
  • Molecular Weight
    1064.31
  • CAS No.
    214978-47-9
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The HIV gag peptide (197-205), with the amino acid sequence AMQMLKETI, is an immunodominant cytotoxic T-lymphocyte (CTL) epitope located within the p24 region of the HIV-1 Gag protein. This peptide is recognized by CD8+ T cells in the context of the H-2d major histocompatibility complex (MHC) class I molecule. Studies have demonstrated that this epitope elicits robust antigen-specific CD8+ T-cell responses, characterized by cytokine production and memory phenotypes, when delivered via viral vectors such as adeno-associated virus (AAV) or adenovirus.

    The peptide has been extensively used in immunological assays, including MHC class I tetramer staining and intracellular cytokine staining (ICS), to evaluate the quality and magnitude of T-cell responses. It serves as a valuable tool for understanding CD8+ T-cell activation, memory formation, and functional avidity in the context of HIV vaccine development.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Lin J, Calcedo R, Vandenberghe LH, Bell P, Somanathan S, Wilson JM. A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque. J Virol. 2009 Dec;83(24):12738-50. doi: 10.1128/JVI.01441-09. Epub 2009 Oct 7. PMID: 19812149; PMCID: PMC2786857.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"