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  • HIV-1 tat Protein (49-57) peptide

HIV-1 tat Protein (49-57) peptide

Not For Human Use, Lab Use Only.

Cat.#: 304251

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Product Information

  • Product Name
    HIV-1 tat Protein (49-57) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    RKKRRQRRR
  • Sequence
    Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.9%
  • Molecular Formula
    C53H106N30O11
  • Molecular Weight
    1339.63
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The HIV-1 tat Protein (49-57) peptide is a short, highly cationic sequence derived from the HIV-1 Tat protein. It consists of nine amino acids, featuring six arginine and two lysine residues, which confer a strong positive charge. This basic cluster is identified as the principal structural determinant responsible for the peptide's ability to adhere to and cross plasma membranes. The mechanism of cellular entry involves initial ionic interactions with anionic cell surface components, such as heparan sulfate proteoglycans, followed by internalization. The precise pathway of translocation remains a subject of scientific investigation, with evidence suggesting involvement of various endocytic processes. It has been successfully shown to deliver a large variety of cargoes, from small particles to proteins, peptides and nucleic acids.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Brooks H, Lebleu B, Vivès E. Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev. 2005 Feb 28;57(4):559-77. doi: 10.1016/j.addr.2004.12.001. Epub 2005 Jan 6. PMID: 15722164.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"