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Product Name
Human SETD7/SET7/9 (His Tag) recombinant protein
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Description
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
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Protein name
Histone-lysine N-methyltransferase SETD7
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Protein short names
1600028F23RIK; SET7; H3K4MT; SET7/9; FLJ21193; SET9; KIAA1717; KMT7; SETD7; MKIAA1717
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Uniprot ID
Q8WTS6
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Gene Name
SETD7; KIAA1717; KMT7; SET7; SET9
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SETD7 (NP_085151.1) (Asp 2-Lys 366) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SETD7 comprises 372 amino acids and has a predicted molecular mass of 41.5 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 94 % as determined by SDS-PAGE
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Validations
Human SETD7 / SET7/9 Protein (His Tag) SDS-PAGE
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