• HIP peptide

HIP peptide

Not For Human Use, Lab Use Only.

Cat.#: 319283

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Optional Service: TFA RemovalWhat's this?

Special Price 127.4 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    HIP peptide
  • Documents
  • Sequence
    H-GQVELGGGNAVEVLK-OH
  • Three letter code
    H-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Asn-Ala-Val-Glu-Val-Leu-Lys-OH
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    95.48%
  • Molecular Formula
    C63H108N18O22
  • Molecular Weight
    1469.63
  • Source
    Synthetic
  • Additional Information
    HIP (hybrid insulin peptide) is a peptide derived from the splicing of insulin and islet amyloid polypeptides. It generates a preferred peptide-binding motif for HLA-DQ8, a genetic risk factor in type I diabetes. HIP is recognized by autoreactive CD4+ T cells, which are involved in the development of type I diabetes. Understanding the mechanism of recognition of HIP peptides by T cells can help in the development of therapies for type I diabetes. The crystal structure of TRBV5+ TCR-HLA-DQ8-HIP complexes provides insights into the recognition mechanism of HIP peptides by T cells, which can be useful in designing peptide-based therapies for type I diabetes.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Tran MT, Faridi P, Lim JJ, Ting YT, Onwukwe G, Bhattacharjee P, Jones CM, Tresoldi E, Cameron FJ, La Gruta NL, Purcell AW, Mannering SI, Rossjohn J, Reid HH. T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8. Nat Commun. 2021 Aug 25;12(1):5110. doi: 10.1038/s41467-021-25404-x. PMID: 34433824; PMCID: PMC8387461.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"