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Product Name
Mouse HMGB1/HMG1 (Fc Tag) recombinant protein
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Description
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
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Protein name
High mobility group protein B1
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Protein short names
HMG3; SBP-1; HMG-1; MCG_144566; DEF; HMG1; MGC103169; AMPHOTERIN; HMGB1; MGC117897; MGC117896; P30; MGC103168; DKFZP686A04236
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Uniprot ID
P63158
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Gene Name
Hmgb1; Hmg-1; Hmg1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse HMGB1 (P63158) (Met 1-Glu 215) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse HMGB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a calculated molecular mass of 53.3 kDa. The apparent molecular mass of the monomer is approximately 57 kDa in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind mouse AGER-His in functional ELISA.
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Validations
Mouse HMGB1 / HMG1 Protein (Fc Tag) SDS-PAGE
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