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Product Name
Human HMGN3 (His Tag) recombinant protein
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Description
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
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Protein name
High mobility group nucleosome-binding domain-containing protein 3
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Protein short names
6330514M13RIK; THYROID HORMONE RECEPTOR INTERACTING PROTEIN 7; TR-INTERACTING PROTEIN 7; PNAS-25; TRIP7; HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 3; BB071015; PNAS-24; 1110002A15RIK
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Uniprot ID
Q15651
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Gene Name
HMGN3; TRIP7; PNAS-24
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human HMGN3 (Q15651-2) (Met1-Asn77) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human HMGN3 consists of 92 amino acids and predicts a molecular mass of 10.2 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human HMGN3 Protein (His Tag) SDS-PAGE
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