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Product Name
Mouse FcERI / FCER1A (Fc Tag) recombinant protein
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Description
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
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Protein name
High affinity immunoglobulin epsilon receptor subunit alpha
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Protein short names
FCEPSILONRI; IMMUNOGLOBULIN E RECEPTOR; FCR-5; FC-EPSILON RI-ALPHA; FC EPSILON RI ALPHA-CHAIN; ALPHA POLYPEPTIDE; HIGH-AFFINITY; RP11-550P17.3; FCERI; FC IGE RECEPTOR; IGE FC RECEPTOR SUBUNIT ALPHA; OF MAST CELLS; FCE1A; HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA; HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR ALPHA-SUBUNIT
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Uniprot ID
P20489
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Gene Name
Fcer1a; Fce1a
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse FCER1A (P20489) (Met1-Gln204) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse FCER1A /Fc is a disulfide-linked homodimer. The reduced monomer comprises 422 amino acids and has a predicted molecular mass of 48 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Mouse FcERI / FCER1A Protein (Fc Tag) SDS-PAGE
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