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Human PDE9A (His Tag) recombinant protein

Cat.#: 502069

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Product Information

  • Product Name
    Human PDE9A (His Tag) recombinant protein
  • Documents
  • Description
    Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
  • Protein name
    High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
  • Protein short names
    PDE9A; FLJ90181; HSPDE9A2; PDE9A1
  • Uniprot ID
    O76083
  • Gene Name
    PDE9A
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human PDE9A (O76083-2) C-terminal segment (Pro 181-Lys 506) was expressed, with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PDE9A consisting of 337 amino acids and has a calculated molecular mass of 40 kDa. It migrates as an approximately 37 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human PDE9A Protein (His Tag) SDS-PAGE

    Human PDE9A Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"