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  • HER2//neu(654-662) GP2 peptide

HER2//neu(654-662) GP2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 304981

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    HER2//neu(654-662) GP2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    IISAVVGIL
  • Sequence
    Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    97.6%
  • Molecular Formula
    C42H77N9O11
  • Molecular Weight
    884.12
  • CAS No.
    160790-21-6
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The HER2/neu-derived peptide GP2, with the amino acid sequence IISAVVGIL, corresponds to residues 654-662 of the HER2/neu protein. This nonapeptide is an HLA-A2-restricted tumor antigen capable of inducing cytotoxic T lymphocytes that react to various epithelial cancers. However, the native GP2 peptide exhibits very low binding affinity for the HLA-A2 molecule, primarily due to subdominant amino acids at its major anchor positions.

    Modifications involving amino acid substitutions, particularly at position 1, can significantly enhance GP2's binding affinity to HLA-A2. For instance, the modified peptide 1F2L10V (sequence FLSAVVGILV) demonstrates improved stabilization of the peptide-HLA-A2 complex and is effectively recognized by GP2-specific cytotoxic T lymphocytes. These alterations increase the immunogenic potential of the peptide while maintaining recognition by T cell receptors directed against the native epitope.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Tanaka Y, Amos KD, Joo HG, Eberlein TJ, Goedegebuure PS. Modification of the HER2/NEU-derived tumor antigen GP2 improves induction of GP2-reactive cytotoxic T lymphocytes. Int J Cancer. 2001 Nov;94(4):540-4. doi: 10.1002/ijc.1508. PMID: 11745441.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"